DEXTER
Dual-Energy X-ray imaging for TargEting Radiotherapy

Objectives

Principal investigators

• Simon Rit, CREATIS, Lyon, France
• Philipp Steininger, radART, Salzburg, Austria

Scientific programme

• Ion range prediction using dual-energy CT
• Cone-beam CT reconstruction using oblique x-ray projections
• 2D/3D image registration with a pseudo non-isocentric x-ray imaging modality

Publications

Journal articles

• N. Arbor, D. Dauvergne, G. Dedes, J.M. Létang, K. Parodi, C. Quiñones, E. Testa, and S. Rit, "Monte Carlo comparison of x-ray and proton CT for range calculations of proton therapy beams", Physics in Medicine and Biology, vol 60, pp. 7585-7599, 2015.

• S. Rit, R. Clackdoyle, P. Keuschnigg, and P. Steininger, "Filtered-backprojection reconstruction for a cone-beam computed tomography scanner with independent source and detector rotations", Medical Physics, vol 43, pp. 2344-2352, 2016.

• G. Vilches-Freixas, J.M. Létang, S. Brousmiche, E. Romero, M. Vila Oliva, D. Kellner, H. Deutschmann, P. Keuschnigg, P. Steininger, and S. Rit, "Technical note: Procedure for the calibration and validation of kilo-voltage cone-beam CT models", Medical Physics, vol 43, pp. 5199–5204, 2016.

• A. Zechner, M. Stock, D. Kellner, I. Ziegler, P. Keuschnigg, P. Huber, U. Mayer, F. Sedlmayer, H. Deutschmann, and P. Steininger, "Development and first use of a novel cylindrical ball bearing phantom for 9-DOF geometric calibrations of flat panel imaging devices used in image-guided ion beam therapy", Physics in Medicine and Biology, vol 61, N592-N605, 2016.

• P. Keuschnigg, D. Kellner, K. Fritscher, A. Zechner, U. Mayer, P. Huber, F. Sedlmayer, H. Deutschmann, and P. Steininger, "Nine-degrees-of-freedom flexmap for a cone-beam computed tomography imaging device with independently movable source and detector", Medical physics, 2017, 44, 132-142.

• G. Vilches-Freixas, J.M. Létang, N. Ducros, and S. Rit "Optimization of dual-energy CT acquisitions for proton therapy using projection-based decomposition", Medical Physics, vol 44, pp. 4548-4558, 2017.

• G. Vilches-Freixas, V. Taasti, L.P. Muren, J.B.B. Petersen, J.M. Létang, D.C. Hansen, and S. Rit "Comparison of projection- and image-based methods for proton stopping power estimation using dual energy CT" Physics in Medicine and Radiation Oncology, vol 3, pp. 28-36, 2017.

• M. Stock, D. Georg, A. Ableitinger, A. Zechner, A. Utz, M. Mumot, G. Kragl, J. Hopfgartner, J. Gora, T. Böhlen, L. Grevillot, P. Kuess, P. Steininger, H. Deutschmann and S. Vatnitsky "The technological basis for adaptive ion beam therapy at MedAustron: Status and outlook" Zeitschrift fur medizinische Physik, vol 17, pp. S0939-3889, 2017.

• C. Zöllner, S. Rit, C. Kurz, G. Vilches-Freixas, F. Kamp, G. Dedes, C. Belka, K. Parodi and G. Landry "Decomposing a prior-CT-based cone-beam CT projection correction algorithm into scatter and beam hardening components" Physics and Imaging in Radiation Oncology, vol. 3, pp. 49-52, 2017.

• G. Vilches-Freixas, C.T. Quiñones, J.M. Létang and S. Rit "Deriving the mean excitation energy map from dual-energy and proton computed tomography" Physics and Imaging in Radiation Oncology, vol. 6, pp. 20-24, 2018.

Conference proceedings articles

• S. Rit and R. Clackdoyle, "2D filtered backprojection for fan-beam CT with independent rotations of the source and the detector", Third international conference on image formation in X-ray computed tomography, pp. 249-252, Salt Lake City, USA, 2014.

• P. Keuschnigg, P. Steininger, H. Schoedl, K. Presich, D. Kellner, P. Huber, U. Mayer, M. Mehrwald and H. Deutschmann "Flat-Field Correction Pipeline for a Cone-Beam Computed Tomography Imaging Device with Independently Movable Source and Detector", ICART workshop, MICCAI, pp. 136-144, Munich, Germany, 2015, oral.

• G. Vilches-Freixas, J.M. Létang, N. Ducros, and S. Rit, "Dual-energy CT spectra optimization for proton treatment planning", Fourth international conference on image formation in X-ray computed tomography, pp. 585–588, Bamberg, Germany, 2016, oral.

Conference abstracts

• P. Keuschnigg, H. Deutschmann, H. Weichenberger, F. Sedlmayer and P. Steininger, "PO-0917: Non-isocentric cone-beam computed tomography reconstruction and artifact suppression", ESTRO, Radiotherapy and Oncology, vol 111, pp. S113–S114, Vienna, Austria, 2014, poster.

• N. Arbor, D. Dauvergne, G. Dedes, J.M. Letang, C.T. Quiñones, E. Testa and S. Rit, "In-Silico Comparison of X-Ray and Proton Computed Tomography for Proton Therapy Dose Simulation with a Full Monte Carlo Treatment Planning", In: IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). Seattle, USA, 2014, poster.

• G. Vilches-Freixas, J.M. Létang, K. Presich, P. Steininger, and S. Rit, "PO-0959: Optimal dose balance between energy levels for material decomposition with dual-energy X-ray CT", ESTRO, Radiotherapy and Oncology, vol 115, pp. S506-S507, Barcelona, Spain, 2015, poster.

• S. Rit, R. Clackdoyle, P. Keuschnigg and P. Steininger, "OC-0410: Exact FBP reconstruction for a cone-beam CT scanner with independent rotations of the source and the detector", ESTRO, Radiotherapy and Oncology, vol 115, pp. S198-S199, Barcelona, Spain, 2015, oral.

• N. Arbor, D. Dauvergne, G. Dedes, J.M. Létang, K. Parodi, C.T. Quinones, E. Testa and S. Rit, "PD-0139: Monte Carlo evaluation of X-ray and proton CT for the prediction of the range of proton therapy beams", ESTRO, Radiotherapy and Oncology, vol 115, pp. S66, pp. 115, Barcelona, Spain, 2015, poster discussion.

• S. Rit, G. Vilches-Freixas, G. Landry, and J.M. Létang, "Spectral CT for proton therapy", Photon Counting CT workshop, Lyon, France, 2015, oral.

• G. Vilches-Freixas, J.M. Létang, and S. Rit, "EP-1847: Comparison of stopping power estimators from dual-energy computed tomography for protontherapy Radiotherapy and Oncology, 2016, S869 ", ESTRO, Radiotherapy and Oncology, vol 119, pp. S689, Torino, Italy, 2016, poster.

• G. Vilches-Freixas, C. Quiñones, J.M. Létang, and S. Rit, "Estimation of the ionization potential map from dual-energy CT and proton CT", PTCOG 55, Prague, Czech Republic, 2016, oral.

• A. Ableitinger, A. Zechner, A. Utz, M. Stock, H. Deutschmann, and P. Steininger, "Geometric accuracy of a couch mounted patient position verification device", PTCOG 56, Tokyo, Japan, 2017, poster.

• M. Stock, G. Kragl, L. Grevillot, A. Ableitinger, H. Palmans, M. Mumot, J. Hopfgartner, P. Steininger, S. Vatnitsky, and E. Hug, "Optimization of a dual particle facility for protons: Acceptance and commissioning results of the whole treatment workflow at MedAustron", PTCOG 56, Tokyo, Japan, 2017, poster.

• A . Utz, A. Ableitinger, A. Zechner, M. Mumot, P. Steininger, H. Deutschmann, and M. Stock, "Implementation of a weight independent patient alignment system: Characteristics and implications on treatment planning", PTCOG 56, Tokyo, Japan, 2017, poster.